NA Epitalon

NA Epitalon (also called NA Epithalon) is a modified form of the synthetic tetrapeptide Epitalon used in preclinical research to study cellular aging biology, including telomerase-associated pathways, oxidative-stress responses, and pineal/circadian signaling.

• What it is: Tetrapeptide with sequence Ala–Glu–Asp–Gly (AEDG) presented in an N-acetylated (NA) form (often written Ac-AEDG).

• Common research use: Investigation of telomerase/telomere-related mechanisms and cell-senescence biology in experimental systems.

• Typical research context: Preclinical models examining oxidative stress, circadian/pineal signaling, and age-associated cellular endpoints.

• What the “NA” portion does (N-acetylation):
  N-terminal acetylation adds an acetyl group to the peptide’s N-terminus. This modification can neutralize the positive charge at the N-terminus, changing electrostatic behavior and sometimes impacting properties like interaction profiles and solubility. In many peptide/protein contexts, N-terminal acetylation is also associated with increased resistance to certain degradation pathways / improved stability, though effects can be sequence- and system-dependent.

For research use only. Not for human or veterinary use. Not for therapeutic or diagnostic use.