
PT-141
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PT-141 (bremelanotide) is a melanocortin-pathway peptide used in research to investigate receptor-mediated neuroendocrine signaling, especially across MC1R/MC4R-linked pathways.
Research class: Melanocortin receptor agonist peptide (PT-141 / bremelanotide).
Primary research purpose: Studying melanocortin signaling pharmacology and downstream neurochemical pathway effects.
Common research endpoints: Receptor-binding potency profiles (MC1R, MC4R, MC3R, MC5R, MC2R), pathway activation markers, and signal-transduction responses.
For research use only. Not for therapeutic or diagnostic applications.
Chemical name: Bremelanotide
Common names: PT-141, PT141
Structure type: Cyclic peptide (lactam-cyclized melanocortin analog; typically N-acetylated)
Identifiers
CAS (free base): 189691-06-3
UNII: 6Y24O4F92S
PubChem CID: 9941379
ChEMBL: CHEMBL2070241
Composition
Molecular formula: C50H68N14O10
Molecular weight (average): 1025.18 g/mol
Monoisotopic mass: 1024.524284 Da
Peptide description (commonly listed)
Commonly described as an α-MSH analog with lactam (Asp–Lys) cyclization and an N-acetylated N-terminus in many catalog descriptions.