PT-141

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 PT-141 (bremelanotide) is a melanocortin-pathway peptide used in research to investigate receptor-mediated neuroendocrine signaling, especially across MC1R/MC4R-linked pathways.

  • Research class: Melanocortin receptor agonist peptide (PT-141 / bremelanotide).

  • Primary research purpose: Studying melanocortin signaling pharmacology and downstream neurochemical pathway effects.

  • Common research endpoints: Receptor-binding potency profiles (MC1R, MC4R, MC3R, MC5R, MC2R), pathway activation markers, and signal-transduction responses.

For research use only. Not for therapeutic or diagnostic applications.

Chemical name: Bremelanotide
Common names: PT-141, PT141
Structure type: Cyclic peptide (lactam-cyclized melanocortin analog; typically N-acetylated)

Identifiers

  • CAS (free base): 189691-06-3

  • UNII: 6Y24O4F92S

  • PubChem CID: 9941379

  • ChEMBL: CHEMBL2070241

Composition

  • Molecular formula: C50H68N14O10

  • Molecular weight (average): 1025.18 g/mol

  • Monoisotopic mass: 1024.524284 Da

Peptide description (commonly listed)

  • Commonly described as an α-MSH analog with lactam (Asp–Lys) cyclization and an N-acetylated N-terminus in many catalog descriptions.